Platform · The engine underneath the practice

One engine. Three intent types. Three deliverable shapes.

The same workflow registry that produces a regulatory brief produces a discovery dossier and a patient-context therapeutic recommendation. The intent object changes; the engine does not. This is the platform under the practice you see in the engagements pages.

01  ·  The engine in one frame

Three input lanes. One engine. Three output types.

A regulatory question, a discovery question, and a patient-context question all enter the same engine through the same intent abstraction. They flow through the same workflow registry, pick up the same review discipline, and exit as the deliverable shape that fits.

Intent · in The engine · invariant Brief · out Intent · 01 Regulatory question pathway · CRL · precedent Intent · 02 Discovery question target · hit · lead · asset Intent · 03 Patient-context question profile · history · pathway Stage 01 Intent object Stage 02 · the heart Workflow registry Stage 03 Source · review Stage 04 Audit-trail bundle Output · 01 Regulatory brief pathway · CRL pattern Output · 02 Discovery dossier target · hit · asset read Output · 03 Therapeutic recommendation ranked · analog · novel Same registry Same review discipline 7-year audit-trail retention Reviewer-signed Inv. 2026.04
A partner scans, doesn't read. The engine, in one frame.
02  ·  Intent

What goes in.

An intent object describes the question and the context it lives in. The engine reads the same shape across regulatory, discovery, and patient-context engagements.

Intent · 01
Regulatory

Regulatory question.

A pathway, a precedent, or a submission-strategy question scoped to an asset, an indication, and a jurisdiction. Reads against the regulatory record across FDA, EMA, PMDA, MHRA, NMPA.

— asset · indication
— pathway hypothesis
— jurisdiction(s)
— precedent window
— audience · deliverable
Intent · 02
Discovery

Discovery question.

A target, a hit, a scaffold, or an asset to evaluate — with the science context and the downstream-development boundary. Reads against the target, chemistry, and IP record.

— target · scaffold
— modality in scope
— therapeutic area
— discovery stage
— hand-off boundary
Intent · 03
Patient-context

Patient-context question.

A patient's specific mutation profile, prior-line history, clinical context, and the regulatory pathway available to act on the answer — from a molecular tumor board or specialty-clinic precision-medicine program.

— genomic profile
— prior-line history
— clinical context · PK
— pathway window
— audience · timeline

The intent object is the input shape. Across all three lanes, it is the same abstraction. New lanes — population health, payer / HTA evaluation, regulatory-portfolio strategy — extend the schema without rebuilding the engine.

03  ·  Workflow registry

Versioned workflows. Composable. Auditable.

The engine is a registry of versioned analytical workflows. Each workflow is auditable end-to-end — its rev is logged on every claim it produces, and a reviewer can replay any output against the cited primary sources.

The intent object is matched to the workflows the question requires. A regulatory pathway question runs the regulatory-pathway workflow against the cited source set; a target validation question runs the validation workflow; a patient-context question runs the re-rank workflow against the patient-specific intent and escalates to analog or novel design where needed. Same engine, different selection.

The platform's capability is not the workflow library. It is the abstraction that lets the same engine pick up a new workflow — from a CRL pattern reading to a deal precedent reading to a patient-context re-rank — and run it against any intent type, with the same review discipline and audit trail. New workflows extend the registry without rebuilding the practice.

Workflow ID Primary use Intent types Status
META-REG-PATHWAY · v3.4 Regulatory pathway analysis Regulatory Production
META-CRL-PATTERN · v3.0 CRL precedent & deficiency read Regulatory Production
META-TARGET-VAL · v2.7 Target validation read Discovery, Patient-context Production
META-COMP-LANDS · v2.5 Competitive landscape Regulatory, Discovery Production
META-IP-FTO · v2.0 IP & freedom-to-operate Discovery Production
META-DEAL-PRECEDENT · v2.0 Deal precedent & comparable terms Discovery Production
META-PT-RERANK · v1.2 Patient-context re-rank Patient-context Beta
META-ANALOG-DESIGN · v1.0 Analog suggestion & profile Discovery, Patient-context Beta
META-NOVEL-GEN · v0.9 Novel matter generation Discovery, Patient-context Alpha

Read the methodology paper library →

04  ·  Capability

Three tiers. One platform. Same engine.

For any intent that asks "what therapeutic fits this target or this patient," the platform answers across an escalation ladder. This is a platform capability, not a service-tier description.

i.
Tier 01 · Re-rank

Score the known space.

The entire known therapeutic space — approved drugs, clinical-stage compounds, literature analogs — scored against the target conformation and intent context. Default entry point for any patient or program intent.

— Hours, not months
— Cited primary record
— Reviewer-signed
ii.
Tier 02 · Analog · if known space exhausts

Minimal-modification analog.

When the known space falls short, propose minimal-modification analogs of the closest scaffold — predicted profile, synthesis route, IP positioning. Engagement escalates from Tier 1 only on demand.

— Predicted ADMET
— Synthesis prioritization
— IP & FTO read
iii.
Tier 03 · Novel · if no precedent fits

Full novel design.

When no precedent fits, generate novel matter against the target — virtual screen, generative chemistry, predicted ADMET and synthesizability. Hand-off package ready for experimental validation.

— Hand-off package
— Predicted profile · analog
— Synthesis route
Same engine across tiers Same review discipline Same audit-trail bundle Escalation on demand

Genomic diagnostics tell you what is wrong at the patient level. The molecular design layer tells you what to do about it at the molecular level. One sells data. The other sells decisions — ranked, escalating, defensible.

05  ·  Trajectory

Where the platform is going.

The engagements visible today are the practice's first surface. The platform underneath was built so the same engine can absorb new intent types and new workflow domains without rebuild. A trajectory, not a roadmap.

Today
Live

Three engagement practices, one engine.

Intelligence Studio, Discovery Engine, and patient-context engagements via molecular tumor boards and specialty clinics — all running the same workflow registry.

Next 6 months
In flight

Workflow registry extensions.

Patient-context re-rank at production rev. IP & FTO at rev 2. Failure-record and trial-design precedent at rev 1. The engine reads more questions, faster.

Next 12 months
Scoped

New intent types.

Population-health intent (cohort-context re-rank), payer / HTA intent (reimbursement-context evaluation), regulatory-portfolio intent (multi-asset pathway optimization). Same engine, new lanes.

Direction
Direction

A platform any team can run a question through.

The marginal cost of a new intent type or a new workflow is the cost of authoring the workflow, not rebuilding the platform. The practice grows by extending the registry.

Trajectory disclosure is honest. The engagements live today are real. The extensions named above are scoped, not shipped. The platform was built for the trajectory; the practice ships against it.